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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
7.27
Human Site:
S365
Identified Species:
12.31
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
S365
R
A
A
V
Q
E
L
S
S
S
I
L
A
G
E
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
R351
E
W
E
W
E
A
Q
R
D
R
G
V
K
L
G
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
E292
I
L
A
G
E
D
P
E
E
R
G
V
K
L
G
Dog
Lupus familis
XP_547503
717
78133
E602
D
S
Y
D
S
F
G
E
P
S
Y
P
E
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S365
R
A
A
V
Q
E
L
S
G
S
I
L
T
S
E
Rat
Rattus norvegicus
P97887
468
52771
S366
R
A
A
V
Q
E
L
S
G
S
I
L
T
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
E363
V
E
E
E
E
E
E
E
E
R
G
V
K
L
G
Chicken
Gallus gallus
Q4JIM4
468
52812
P366
R
A
A
V
Q
A
L
P
S
N
S
Q
T
S
E
Frog
Xenopus laevis
O12976
433
48282
E341
S
P
P
S
E
D
P
E
E
R
G
V
K
L
G
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
P358
M
P
S
A
R
P
P
P
P
A
D
D
D
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
P386
V
L
A
T
E
G
M
P
L
V
T
F
K
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
E352
D
A
N
F
H
R
H
E
E
E
E
R
G
V
K
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
V406
S
E
D
R
R
A
A
V
R
A
L
R
Q
N
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
D358
A
R
G
L
E
E
S
D
N
V
V
D
I
S
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
0
6.6
6.6
N.A.
80
80
N.A.
6.6
53.3
0
6.6
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
13.3
26.6
13.3
N.A.
80
80
N.A.
20
60
20
26.6
N.A.
20
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
36
43
8
0
22
8
0
0
15
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
8
8
0
15
0
8
8
0
8
15
8
0
0
% D
% Glu:
8
15
15
8
43
36
8
36
29
8
8
0
8
8
36
% E
% Phe:
0
0
0
8
0
8
0
0
0
0
0
8
0
0
8
% F
% Gly:
0
0
8
8
0
8
8
0
15
0
29
0
8
8
29
% G
% His:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
22
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
36
0
8
% K
% Leu:
0
15
0
8
0
0
29
0
8
0
8
22
0
29
0
% L
% Met:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
8
8
0
0
0
8
22
% N
% Pro:
0
15
8
0
0
8
22
22
15
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
29
0
8
0
0
0
0
8
8
0
0
% Q
% Arg:
29
8
0
8
15
8
0
8
8
29
0
15
0
0
0
% R
% Ser:
15
8
8
8
8
0
8
22
15
29
8
0
0
36
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
8
0
22
0
0
% T
% Val:
15
0
0
29
0
0
0
8
0
15
8
29
0
15
0
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _